By Kai-Uwe Lewandrowski
Advances in Spinal Fusion finds a brand new new release of fabrics and units for more advantageous operations in spinal fusion. This reference showcases rising learn and applied sciences in components resembling biodegradable implants, drug supply, stem mobile isolation and transfection, phone encapsulation and immobilization, and the layout of 2nd and 3D scaffolds for cells. It captures a cascade of options an important to elevated therapeutic and diminished morbidity in spinal fusion equipment and mechanics and addresses present criteria in analytical technique and qc, it describes the choice of biomaterials for greater biocompatibility, biostability, and structure/function relationships.
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Additional info for Advances in spinal fusion : molecular science, biomechanics, and clinical management
J. Orthop. Res 1988; 6:293–299. 50. Jensen ME, Kallmes DF, Short JG, Schweikert PJ, Marx WF. Percutaneous vertebroplasty does not increase the risk of adjacent vertebral fracture—a retrospective study. Presented at the 38th Annual Meeting of the American Society of Neuroradiology, Atlanta, GA, April 3, 2000. 51. Barr JD, Barr MS, Lemley TJ, McCann RM. Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine 2000; 25:923–928. 52. Lyles KW, Gold DT, Shipp KM, Pieper CF, Martinez S, Mulhausen PL.
Vertebroplasty, initially an open procedure, introduced bone graft or some biomaterial, typically polymethylmethacrylate (PMMA) cement, into vertebral bodies (VBs) [2–4,6–12]. Percutaneous vertebroplasty (PV), a relatively new variant, is performed by injecting acrylic cement into VBs via cannulae. This procedure was reportedly first performed in 1984 to stabilize a C2 vertebra invaded by an aggressive hemangioma . The successful mechanical stabilization of the VB and the resulting pain relief experienced by the patient led investigators to adapt the procedure for patients with painful osteoporotic vertebral compression fractures .
Furthermore, as treatments for primary tumors become more effective, resulting in longer periods of patient survival, the incidence of metastatic lesions increases. The spine is the most common site for metastases, and osteolytic metastases and myeloma are the most frequent malignant lesions occurring in the spine . PV is being used more frequently to augment mechanically VBs compromised by lytic lesions. Accompanying the increase in the practice of PV are increases in the number of clinical investigations into the efficacy of the procedure and of basic science investigations into evaluating materials, instruments, and techniques.
Advances in spinal fusion : molecular science, biomechanics, and clinical management by Kai-Uwe Lewandrowski